medical device development

AcQumen Medical, Inc. is a medical device company based in Minneapolis, MN, focused on pediatric and neonatal critical care. Its team of medical device professionals is dedicated to enhanced clinical data for healthcare professionals and improved patient outcomes. The company developed UltraTrac, described as the first multi-element non-invasive hemodynamic monitoring system powered by ultrasound, combining the accuracy of ultrasound with the ease of use of impedance measurements to measure cardiac parameters for patients of any size.

impedance measurementsultrasound-based hemodynamic monitoring

Actuated Medical, Inc. is a clinical-stage medical device company headquartered in Bellefonte, Pennsylvania, developing innovative motion-based technologies to solve challenging clinical problems. It is advancing NeuralGlider®, a precision brain access and deep brain therapy delivery platform that uses electronically controlled ultrasonic motion to help maintain the desired trajectory during insertion through delicate brain tissue.

deep brain therapy deliveryelectronically controlled ultrasonic motionprecision brain access

Adroit Surgical, LLC. is a privately funded medical device company that has developed a patented method for securing the difficult airway in emergency situations, an alternative to video laryngoscopy and in some cases cricothyroidotomy. Its products aim to make intubation faster, safer and less expensive, with the Vie Scope offering paramedics and doctors the ability to handle all adult intubations using only one device.

airway management / intubation

Agitated Solutions, Inc. (ASI) is a Minnesota-based medical device company developing tools to improve ultrasound imaging and aid in diagnosis across multiple clinical applications. Its first product, the Orbis Microbubble Generator, is an ultrasound imaging agent for saline contrast echocardiography studies, licensed in Canada in early 2024. ASI is also developing a novel saline microbubble contrast agent (ASI-02) and a software algorithm to characterize cardiac shunt severity.

clinical trialsultrasound imaging

Ampulis develops Pristal, a dual-chamber syringe (DCS) that reconstitutes lyophilized biologics from two independent, standard cartridges rather than stacked coaxial chambers. Removing the cap triggers an internal spring that pierces both cartridges and automatically transfers diluent into the lyo cartridge; the user then agitates to confirm reconstitution and doses with a single plunger stroke. Ampulis owns all Pristal IP, and Pristal is engineered with Archimedic covering design, verification, quality, and manufacturing transfer.

combination productsdesignmanufacturing transferqualityverification

Angel Medical Devices develops medical devices and accessories that consolidate and simplify the overburdened medical care environment, improving ergonomics in the Operating Room, Hybrid Room and ICU. Founded by practicing clinicians in partnership with hospital administrators, industrial designers and engineers, the company aims to eliminate waste and inefficiencies in the perioperative process to enhance workflow, throughput, and safety for patients and providers.

Ergonomic DesignQA/QC inspection and testing

Annoviant is a healthcare innovation company and medical device startup based in Alpharetta, Georgia, dedicated to developing medical devices that transform and save lives worldwide. Its patented TxGuard technology consists of decellularization of biological tissue, stabilization with patented chemistry, and sterilization using a proprietary process, designed to regenerate with patients' own cells and grow with the patient.

decellularization of biological tissuestabilization with patented chemistrysterilization using a proprietary process

Apex Biomedical, LLC is a collaboration between medical professionals and engineers that delivers Research and Development consulting services for the treatment of traumatic skeletal injuries and prevention of traumatic brain injuries. Founded in 2004, its work has led to four commercial products in the health science space with 16 U.S. patents granted, exclusively licensed to US-based market leaders. Current work focuses on Active Plating of skeletal fractures and improved bicycle helmet technology to reduce rotational acceleration during impact.

biomechanics researchResearch and Development consulting

Aplos Medical is a medical device company focused on a next-era treatment for gastroesophageal reflux disease (GERD). It develops Omega PF™, a small Ω-shaped implant designed to prevent excessive acid from entering the esophagus while allowing much of the normal swallowing process to remain intact, implanted via a laparoscopic procedure. The device is patented in the U.S., China, and Europe and has achieved FDA IDE approval. The team has combined experience introducing over 200 products to market.

clinical studieslaparoscopic implantation procedure

Arsenal Medical is a medical device company that develops biomaterials-based products. Its platform includes NeoCast, an injectable shear-responsive material for deep neurovascular occlusion, and ResQFoam, a rapidly expanding hydrophobic foam designed to control hemorrhage in abdominal trauma. The company was founded by Carmichael Roberts, Robert Langer, and George Whitesides, and is led by CEO Upma Sharma.

biomaterials developmentclinical trialsRegulatory Affairs

Artivion is a medical device company focused on developing solutions for cardiac and vascular surgeons treating patients with aortic diseases. Its technologies include aortic stent graft systems, heart valves, surgical adhesives, and mitral chordal replacement products. The company states it has 1,600+ global employees and manufacturing facilities in Georgia, Texas, and Hechingen, Germany.

clinical researchmanufacturing

Aspira Therapeutics is developing Aspirvent, a first-in-class alginate-based intragastric barrier device that forms a coherent gel raft on the gastric surface to physically prevent pulmonary aspiration during anesthesia induction and sedation. The company is prioritizing patients on GLP-1 therapy before expanding into broader pre-operative gastric-content protection.

alginate gel-raft formulationCMC developmentGMP-grade formulation manufacturing

AssurTek Surgical was founded with the mission to improve accessibility to quality care by empowering dental professionals and patients through innovative technology. The company develops OsteoSmartSense, described as the world's first AI-powered smart-sensing dental drill technology, which provides real-time detection of nerves, sinuses and other vital structures to mitigate risks during dental implant surgery.

AI-backed real-time algorithmbioimpedance-based technologiesdigital system designFPGA-based instrumentationsensor-based diagnosticssignal processing

Atrility Medical is a medical device company focused on cardiac health and improving patient lives through advances in medical technology. It developed the AtriAmp, an FDA-cleared device for pediatric and adult patients that provides continuous atrial electrograms in real-time on the ICU patient monitor by connecting temporary atrial pacing wires, the bedside monitor, and a temporary pacemaker. The company aims to bring cardiac medical devices to market by integrating healthcare, business, and engineering specialists.

cardiac monitoring technology

AVAcore Technologies, Inc. is a medical device company dedicated to developing thermo-regulation systems and vasodilation modulation technology. Its warmUP™ is an FDA-cleared, non-invasive, fluid-based perioperative patient warming system that rapidly warms and enhances blood flow through the hand. The company was founded by two Stanford University PhDs conducting research in mammalian thermo-regulation under a DARPA grant.

thermo-regulation systemsvasodilation modulation technology

Biophys Ltd is an R&D consultancy and laboratory services provider that advises biomedical, life science and food companies. It offers business management, R&D, product innovation, regulatory and compliance experience, and specialised microbiology and cell biology laboratory services, partnering with clients to translate ideas into commercialisable products and services. It also works in CXO and fractional roles such as CEO, CSO and COO.

cell biology laboratory servicesdiagnostic device developmentfood safety solutionsmicrobiology laboratory servicesproduct innovationR&D consultancyregulatory and compliance

BioWave Corporation is a Medtech company based in Westport, CT, that develops FDA-cleared, CE-certified, non-invasive neuromodulation technology for drug-free pain relief. Its patented high-frequency neurostimulation blocks pain signals at the nerve source, used in VA hospitals, professional sports, clinical settings, and at home.

clinical studieshigh frequency neurostimulationneuromodulationnon-invasive pain reliefR&D

BiVACOR is a clinical-stage medical device company pioneering the development of a long-term therapy for patients with biventricular heart failure. It develops a Total Artificial Heart (TAH), an electro-mechanical rotary blood pump with a single magnetically levitated rotor that pumps blood to both the body and lungs. The TAH is undergoing an FDA-approved first-in-human Early Feasibility Study, with first implantation completed July 9, 2024. Headquartered in Huntington Beach, California, with clinical offices in Houston, Texas, and international offices

centrifugal rotary blood pump designclinical studiesmagnetic levitation (MAGLEV) technology

Bluedrop Medical was founded in 2015 by Chris Murphy and Simon Kiersey and is headquartered in Galway, Ireland. The company exists to help end unnecessary diabetic amputations. It developed an at-home smart scale that scans feet in less than 30 seconds per day, collecting high-resolution images and temperature analysis, along with a monitoring service that identifies and communicates risks to users and their physicians.

Artificial intelligencedistributionhardware and software developmentlean manufacturingregulatory

BrainSonix is a medical device company developing Low-Intensity Focused Ultrasound Pulsation (LIFUP) technology, a form of transcranial focused ultrasound stimulation (tFUS), for non-invasive, targeted neuromodulation of the brain. Founded by Dr. Alexander (Sasha) Bystritsky, a neuropsychiatrist and UCLA professor who invented and first demonstrated LIFUP for human brain modulation, the company is based in Los Angeles, CA. Its devices are used under FDA Investigational Device Exemptions in clinical trials.

focused ultrasound neuromodulationMRI-compatible device designreal-time monitoring and targetingtranscranial focused ultrasound stimulation (tFUS)

C2C Inc. is dedicated to innovative medical research and revolutionising the development of medical devices. Its mission is to enhance life-saving results through medical devices that save lives in emergency situations around the globe. The company is located at 16192 Coastal Highway, Lewes, DE, USA.

medical research

Calmare Therapeutics Incorporated (OTCQB: CTTC) is a biotherapeutic company that researches, develops and commercializes chronic, neuropathic pain and wound affliction devices. Its flagship product, the Calmare® Pain Therapy Device, is a non-invasive, non-addictive, non-pharmacological treatment for chronic pain. The company also licenses technologies and provides technology sourcing and IP licensing services.

patent application and analysispatent enforcement litigation managementroyalty collection, distribution and auditingtechnology licensingtechnology sourcing

Calyxo is a medical device company founded in 2016 focused on improving care for patients with kidney stones. Its CVAC System is an all-in-one kidney stone treatment system used in the SURE (Steerable Ureteroscopic Renal Evacuation) Procedure, a minimally invasive treatment using laser lithotripsy, irrigation, and vacuum aspiration to achieve stone clearance.

dynamic aspirationlaser lithotripsymicrojet irrigationstone collection

CaroRhythm Inc. is a medical device company focused on improving stroke care beyond the hospital. It is developing a continuous outpatient stroke monitoring device, called CaroSense, to help stroke survivors and clinicians with early stroke detection. The company was made at NYU Tandon School of Engineering, has a completed proof of concept study, and won the 2023-24 NYU Langone Health PoC Study.

biophotonicsstroke monitoring