clinical trials

Diastol Therapeutics is an emerging biotechnology company developing a treatment for Heart Failure with Preserved Ejection Fraction (HFpEF) as its lead program. Founded in 2018, it is located in Chicago, IL/Minneapolis, MN, and aims to build a cardiovascular-focused company treating leading causes of death and morbidity. Its lead drug candidate is a first-in-class compound with a validated target, with ongoing non-human primate studies and IND filing planned within 18 months of financing.

CMC and tox studiesdrug developmentnon-human primate studiesPD assays

Dompé farmaceutici S.p.A. is a global biopharmaceutical company founded as Milan's first compounding pharmacy and grown over 130 years. It straddles primary care and biopharma, harnessing nerve growth factor (NGF) to develop first-in-class disease-modifying therapies across ophthalmic, neurological and pain-related indications. It engineered and manufactured the first recombinant human nerve growth factor (rhNGF) and developed the Exscalate virtual screening platform.

biotech manufacturingGMP manufacturingrecombinant human nerve growth factor (rhNGF) engineeringresearch and developmentvirtual screening (Exscalate)

Dr. Vince Clinical Research is a full-service CRO built specifically for early phase drug development, specializing in Phase I-III clinical trials across a wide range of study designs, therapeutic areas and drug classes. Studies are conducted at its 80,000 square-foot research campus in Overland Park, Kansas, which houses a 100-bed Phase I clinical pharmacology unit, an in-house clinical laboratory and a cGMP-compliant pharmacy. The company was founded by Bradley D. Vince, DO, CEO and Chief Medical Officer.

biostatistics and programmingcGMP-compliant pharmacyclinical monitoringCTMSdata managementEDCeSourcein-house clinical laboratorymedical monitoringmedical writingPhase I clinical pharmacology unitPK modeling and simulationPK/PD analysisproject management

EarSmartAI is a medical software company dedicated to solving ear infections, the most common health concern among young children. Its integrated system features the EarSmartAI mobile app, a connected otoscope, and proprietary AI algorithms that let parents capture an eardrum video and receive an AI likelihood result, aiming to improve diagnostic accuracy from today's 50% average to over 90%. Validated in peer-reviewed clinical studies (JAMA, 2024) and backed by more than a decade of scientific research.

AI-powered diagnostic algorithmsconnected otoscopemobile app developmentregulatory submission

EicOsis Human Health is a clinical-stage pharmaceutical company developing oral medicines targeting soluble epoxide hydrolase (sEH) to treat pain, inflammation, and neuroinflammatory and neurological disorders. Its lead drug candidate, EC5026, is a first-in-class oral sEH inhibitor being studied as a non-opioid treatment for neuropathic pain, Parkinson's disease, Alzheimer's disease, and other conditions.

drug discoverysEH inhibitiontranslational science

Eisai Inc. is the U.S. company of Eisai Co., Ltd., a pharmaceutical company guided by its human health care (hhc) mission, placing patients and their families first. With almost 40 years of research, development and manufacturing in the U.S., Eisai focuses on drug discovery for challenging neurological conditions such as Alzheimer's disease, sleep disorders and narcolepsy, and on oncology toward a cancer-free future.

drug discoverymanufacturingresearch and development

Elixirgen Therapeutics develops life-changing therapies for rare diseases and aging-associated diseases using its ZSCAN4 and Bobcat® mRNA technologies. Its ZSCAN4 technology is in clinical trials to extend telomeres in patients with Telomere Biology Disorders, and its Bobcat® mRNA technology delivers large payloads such as full-length dystrophin for Duchenne muscular dystrophy.

autologous cell therapymRNA designstem cell biology

ELPIS Pain Center, LLC is a pain management center in O'Fallon, Missouri, specializing in the management and treatment of acute and chronic pain through a multidisciplinary approach. Its Medical Director, Dr. Vivek Manchanda, advocates Evidence Based Medicine and is involved in clinical trials of new medications.

multidisciplinary approachnerve ablationsnerve blockspain managementphysical therapypsychotherapysurgical implants

Elysium Health creates clinically proven longevity supplements developed with world-leading scientists, aiming to promote optimal aging and target cellular health. Its products include Basis, an NAD+ supplement developed by co-founder and chief scientist Leonard Guarente, Ph.D., along with other supplements and the Index Biological Age Test. The company reports 25+ scientific advisors, NSF Certified for Sport, third-party testing, and 16+ ongoing and completed human clinical trials.

NSF Certified for Sportresearch collaborationsthird-party purity and quality testing

EMBioSys was founded in 2022 with a mission to develop innovative bioelectric solutions that transform the future of cancer care. The company has developed Efinia™, a wearable platform technology for induced Electric Field (iEF) Therapy, and is entering clinical trials for the treatment of cancer, starting with breast cancer.

bioelectric solutionsinduced Electric Field (iEF) Therapyprototypingresearch and development

EMF Disturbance Monitors, Inc. is a Delaware corporation headquartered in Fripp Island, SC, founded in 2011 by Dr. Paul C. Browne. The company has developed a patented medical test based on electromagnetic field disturbance theory, designed to estimate the 'charge' of the heart or brain to help diagnose diseases caused by decreased cellular energy production. It is beginning a planned FDA Phase II human trial to determine whether its technology can accurately diagnose advanced congestive heart failure in adults.

electromagnetic field disturbance testingmedical diagnostics

Enalare Therapeutics Inc. is a clinical-stage biopharmaceutical company developing novel therapies for life-threatening acute respiratory and critical care conditions. Its lead drug candidate, ENA-001, is a patent-protected new chemical entity with a novel mechanism of action, beginning additional clinical trials in the fourth quarter of 2021, targeting conditions such as drug overdose respiratory depression and apnea of prematurity. The company is located in Rowan University's Samuel H. Jones Innovation Center in Mullica Hill, NJ.

drug development

ENA Respiratory is a clinical-stage pharmaceutical company headquartered in Melbourne, Australia, with operations in the USA. It develops antiviral host defense enhancers for the prevention of severe complications from respiratory viral infections in vulnerable populations. Its lead product is INNA-051, a first-in-class TLR2/6 agonist developed as a self-administered nasal product with a weekly dosing regimen. The company was formed in 2020 as a spin-off from ENA Therapeutics Pty Ltd.

clinical-stage pharmaceutical developmentdrug development

Labcorp's Esoterix laboratories, formerly Endocrine Sciences and Colorado Coagulation, provide specialized laboratory testing in endocrinology and coagulation with over 40 years of experience. The Endocrinology Center of Excellence (formerly branded Endocrine Sciences) is a research-quality reference laboratory specializing in highly specific and sensitive endocrine testing, including mass spectrometry assays and age- and gender-related reference intervals.

electrochemiluminescence (ECL)mass spectrometry (HPLC/MS-MS)molecular analysisphysician-to-physician consultationspreanalytical sample extraction and purificationreflex cascade testing

Enterprise Sensor Systems (EnSenSys) is developing technology to rapidly detect the presence or absence of pathogens in humans, animals, and the environment using hyperspectral imaging and artificial intelligence to identify spectral signatures of threats. Formed in 2020 as a collaboration of small businesses and a university medical research center, the team develops rapid, non-invasive, subject-agnostic screening devices to determine in seconds if an individual is positive for a respiratory viral infection. They are in their second series of human clin

artificial intelligence spectral analysishyperspectral imagingmedical device research and developmentsensing technology development

Eolas Therapeutics is a biotechnology company focused on developing novel therapies for addiction and other neurological disorders. It leverages neuroscience to develop therapies targeting the brain's reward system by modulating specific neural pathways to treat addiction and related disorders.

neuroscience researchtherapy development

EPI-Q, Inc. is a certified small business and scientific agency and consultancy providing health economics and outcomes research and population health research services to generate real-world evidence for the life sciences industries. Founded in 1994, its interdisciplinary staff includes epidemiologists, economists, statisticians, physicians, pharmacists, nurses, and quality improvement experts.

claims and electronic medical record analysisepidemiologic modelinghealth economics and outcomes researchMeta-analysisquality improvementreal-world evidence generationsurveys

ES Research Center is a medical research organization focused on advancing knowledge through structured clinical and healthcare studies. Its work is guided by scientific rigor, ethical standards, and a commitment to clear, transparent reporting. It conducts clinical trials and healthcare research to support evidence-based decision-making and improve health outcomes.

clinical studieshealthcare researchpublications

Estrigenix Therapeutics, Inc. was formed in 2018 to develop and commercialize first-in-class therapeutics to treat and prevent hot flashes and dementia in post-menopausal women. It is a privately held pharmaceutical company working on a family of compounds to address menopause symptoms, moderating hot flashes and improving memory without the risks of breast cancer and stroke associated with traditional hormone replacement therapy, based on expertise in estrogen biology.

drug discovery and developmentestrogen biology researchmedicinal chemistrypharmacology

Eton Pharmaceuticals is an innovative pharmaceutical company that searches the world over for meaningful therapies to bring to patients living with rare diseases. It discovers and develops therapies for small patient populations, sourcing potential therapies worldwide and navigating the drug development and FDA approval process to bring promising therapies to market. The company has brought multiple approvals to market in just 4 years, with more in the pipeline.

commercializationdrug discovery and developmentFDA approval navigationsourcing therapies worldwide

Evolve Biologics is a biologics company founded to bring critical plasma proteins to people who need them. It develops plasma-derived therapeutics using its patented PlasmaCap EBA technology, which it describes as the first major advancement in plasma protein extraction in over 80 years, aiming for higher purity, efficiency, and reliability. Its pipeline is initially based on two proteins, IVIG and albumin, with a human Phase III clinical trial for IVIG underway.

manufacturingPlasmaCap EBA technologyplasma protein extraction

Exeltis USA, Inc. (formerly Everett Laboratories) is an independent, family-owned women's healthcare company focused on delivering better health options to patients. Founded in 1971, it entered the women's health market in the mid-1990s with a focus on pre-natal supplementation and has since brought other women's health products to market. It is part of the global InSud Pharma group and operates through a network of more than 40 subsidiaries.

research and development

Exvade is an oncology-focused company developing the Tumor Monorail Device, which uses bio-inspired cues to guide invasive brain tumor cells into a small, accessible reservoir where they can be safely removed and analyzed. The company is conducting a First-in-Human study of the device at the Preston Robert Tisch Brain Tumor Center at Duke University to evaluate its safety.

precision tumor removalreal-time tissue analysistargeted drug delivery

Faebris Medical is a full-service adult infectious diseases medical practice in southwest Atlanta, GA. Dr. Zandraetta Tims Cook, MD, MPH is the medical director and primary physician. The practice is affiliated with Grady Hospital, Southern Regional Medical Center and the Piedmont health system. Services are provided by a board-certified infectious diseases specialist/internist and a certified family nurse practitioner with over 25 years of combined medical experience. It has an on-site lab for phlebotomy and an infusion suite for intravenous medications

Community educationinfectious disease treatmentIV infusionsphlebotomy