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of page< Back Substance Misuse Substance Use Disorder (SUD) is a clinical diagnosis defined by the presence of specific criteria in the Diagnostic and Statistical Manual of Mental Disorders (DSM-5). It involves a maladaptive pattern of substance use leading to clinically significant impairment or distress, manifested by at least two of the following within a 12-month period: Increased tolerance to the substance Withdrawal symptoms when not using the substance Unsuccessful efforts to cut down or control use Spending a lot of time obtaining, using, or recovering from the substance Craving or a strong desire to use the substance Continued use despite knowledge of physical or psychological problems caused or exacerbated by the substance Neglecting responsibilities at work, school, or home Giving up important social, occupational, or recreational activities Using the substance in hazardous.
