synthetic biology

A-Alpha Bio is a Seattle-based biotechnology company founded in 2017 at the University of Washington's Institute for Protein Design and Center for Synthetic Biology. It harnesses synthetic biology and machine learning to measure, predict, and engineer protein-protein interactions, using its AlphaSeq experimental platform and AlphaBind computational platform for in-house therapeutic programs and partnerships with pharmaceutical companies.

antibody discoverybinding prediction from protein sequencehigh-throughput protein-protein interaction measurementmachine learningprotein interface engineering

AlpaCure's mission is to revolutionize TB diagnostics by developing effective and user-friendly solutions that are affordable and accessible, particularly for economically disadvantaged communities. AlpaCure harnesses the alpaca immune system, combining it with advanced machine learning and synthetic biology, to engineer ultrapotent antibody fragments for next-generation diagnostic applications.

antibody fragment engineeringdiagnostics developmentmachine learning

Biocognon LLC is a Pittsburgh, PA startup co-founded in early 2023 by Carnegie Mellon University scientists Dr. Christopher Szent-Gyorgyi and Dr. Robert van de Weerd. It is developing a Nanobody discovery platform based on patented fluorogen activating proteins and a combinatorial yeast screening platform for discovery of Nanobodies for therapeutic and diagnostic antibodies.

Artificial IntelligenceBioinformaticscombinatorial yeast screeningmachine learningnext-generation sequencing

BloomBiome is a San Diego-based biotech startup developing next-generation probiotic skincare. By enhancing the native skin microbiome with synthetic biology, it creates safe, sustainable solutions that enhance the skin's natural functions for long-lasting beauty and resilience. Its technology uses skin-native bacteria to deliver bio-actives precisely where needed, addressing penetration and stability issues of conventional skincare. Its flagship prototype, BB-001, is in active development, targeting peptide-driven skin renewal.

engineered microbiomespeptide delivery

Cambridge Consultants is described on its site as the deep tech powerhouse of Capgemini, delivering deep tech innovation that harnesses radical science and engineering to create new technologies, services and products for clients across industries including aerospace, defence, energy, life sciences, medical devices, pharmaceuticals, semiconductor and telecommunications.

analytical testingCNC machiningdesign for manufacturingEmbedded Softwarehuman-centred designmechanical designmicrofluidicsmillingnew product introductionprototypingradio frequency engineeringweldingwire harness and cable assemblywireless development

Codagenix is combining live-attenuated virus design with codon deoptimization technology for a synthetic biology-based platform aimed at infectious disease. It designs hundreds of precise, stable edits into a viral genome to deliver vaccine solutions with the broad immunity benefits of live-attenuated viruses combined with safety, speed and scalability. The company is headquartered in Farmingdale, NY, and considers preclinical and clinical stage collaboration opportunities.

codon deoptimizationlive-attenuated virus designviral genome engineering

Cyclobiome develops bio-engineered microbial extraction technologies for critical minerals and bio-mining. The company uses synthetic biology to create scalable microbial products that enable domestic metal production from low-grade ore, aiming to reduce CAPEX, OPEX, energy use, chemical inputs, and CO2 emissions. Based in Irvine, California.

bio-based mineral extractionbiocontainmentgenetic circuit designmicrobial engineeringmicrobial genome sequencing

DIOSynVax customises vaccine antigen design to maximise protection against existing and future viruses. Its patent-protected method combines computational biology with in vitro and in vivo validation to select Vaccine Antigen Payload (VAP) candidates. The company targets high-consequence viruses including influenza, haemorrhagic fever, and coronaviruses such as SARS-CoV-2, and partners with leading organisations to advance vaccine solutions.

Artificial Intelligencecomputational biologyGenomicsimmunologyin vitro validationin vivo validationpreclinical and clinical testing

DMC Biotechnologies is a U.S.-owned ingredient company developing high-purity, science-backed bioactives for health, wellness and personal care. Using precision fermentation, it produces traceable, consistent ingredients, with its first branded platform KeyPura™ offering myo-inositol and D-chiro-inositol for applications including women's health, metabolic wellness, and beauty and personal care.

downstream purificationmetabolic engineeringprecision fermentationprocess development and scale-up

Eligo Bioscience is deploying in vivo gene editing technologies against microbiome targets to address diseases with high unmet needs. It has developed a first-in-class proprietary GEM (Gene Editing of the Microbiome) platform to edit the microbiome gene repertoire in vivo, and was founded by the inventors of CRISPR-based bacterial precision killing.

CRISPR-based bacterial precision killingimmunologyin vivo gene editingMicrobiologyphage biology

Emerald Cloud Lab operates a highly automated remote controlled life science laboratory in Austin, accessible from anywhere in the world. Founded by scientists for scientists, its mission is to empower scientists to transcend the laboratory through a single software interface to the entire laboratory, accelerating R&D in pharmaceutical research, materials science, medical diagnostics, and agriculture.

biophysical chemistrychemical biologycompendial testinggenetic engineeringhighly automated laboratoryremote controlled laboratorysample preparation

Hitherto AI develops ethical, relational, and enduring forms of intelligence for organizations and research environments. Its work spans research, architecture, consultancy, and education, including AI alignment, model evaluation, federal and enterprise training, and red teaming. It operates through Flux Hall (learning wing), Reason Forge (ethics lab and philosophical gymnasium), Friction Lab (trauma-informed red teaming), and Fathom Lab (closed R&D facility).

AI alignmentcomplex systems modelingcurriculum developmentedge inferenceelectromagnetic sensinginstrumentation designmodel evaluationnon-destructive testingpolymer characterizationRed Teamingsensor fusionspectroscopysynthetic dataset generationSystem architecturetraining and upskilling

Khufu Therapeutics is a regenerative medicine company developing AI-guided, whole human livers to disrupt organ transplantation. Its proprietary platform integrates synthetic biology, organ engineering, and AI-driven computational modeling, using in vitro/in vivo manufacturing and tissue perfusion to grow personalized or allogeneic full-scale livers in about two months. The company was founded by Dr. Natesh Parashurama, MD PhD, and focuses on addressing end-stage liver disease and cirrhosis.

AI-driven computational modelingin vitro/in vivo manufacturingliver organoid growth and differentiationorgan engineeringtissue perfusion