precision fermentation

C1iN is a biotech company building a microbial platform based on thermophilic methane-consuming microbes discovered in the California desert. Using precision fermentation, it develops products for agriculture, skincare, and protein markets, including a soil enhancer that improves heat and drought resilience and a natural melanin for skin protection. The team is grounded in over a decade of science at San Diego State University.

bioengineeringmicrobial platformresearch collaboration

CB Therapeutics is a precision synthetic biology company based in Carlsbad, CA that designs, develops, and manufactures rare molecules at precision fermentation scale. The company grows compounds in engineered yeast rather than foraging or crop extraction, using an AI-guided platform that iterates through plan, build, test, and iterate cycles to improve titer, purity, and consistency. It reports 100+ compounds generated, 8 granted US patents, and 12 years of continuous operations.

AI-guided platformbiosynthetic pathway designcomputational gene miningdownstream chemistryenzyme engineeringphylogenomic and proteomic searchretrosynthetic designyeast strain engineering

Cellibre uses biology as a manufacturing technology, employing nature's machinery to make products more sustainably. The company works in strain engineering, biochemistry and protein engineering, and precision fermentation, designing microbes that make products and moving production from farms to fermentation.

analytical chemistrybiochemistrybioprocessingprotein engineeringstrain engineering

Checkerspot is a biology-driven company founded in 2016 that develops next-generation healthy fats and oils using microalgae and precision fermentation. As a Public Benefit Corporation, it creates specialized lipids and ingredients for food, nutrition, and wellness brands, including nutritional oils, bioactive fatty acids, and designer tropical fats.

biotechnologymicroalgae strain developmentmolecular strain improvement

De Novo produces NanoFerrin™, a nature-identical bovine lactoferrin (bLf) made by precision fermentation instead of dairy extraction. Its host platform and patented DSP process enable production of high and consistent quality/purity lactoferrin at lower costs and higher volumes, with specified iron saturation, purity, and sequence identity on every batch.

patented DSP process

DMC Biotechnologies is a U.S.-owned ingredient company developing high-purity, science-backed bioactives for health, wellness and personal care. Using precision fermentation, it produces traceable, consistent ingredients, with its first branded platform KeyPura™ offering myo-inositol and D-chiro-inositol for applications including women's health, metabolic wellness, and beauty and personal care.

downstream purificationmetabolic engineeringprocess development and scale-upsynthetic biology