physics-based simulation

Aionics, Inc. uses artificial intelligence and physics-based simulation to design new, customized formulations for high performance systems including electric vehicle and aerospace batteries, long-duration energy storage systems, and decarbonized manufacturing. Founded in 2020, the company screens billions of formulations to find candidates for desired performance profiles and co-innovates with companies in electric vehicles, aviation, grid-scale storage, and green manufacturing.

Artificial Intelligencehigh-performance computingmachine learningmaterials screeningquantum mechanical simulation

Crossflow Technologies is located in Huntsville, Alabama, and primarily supports customers in the Aerospace and Defense industries. It builds teams of top-tier professionals to support the evolving needs of its customers, with a vision of developing a community of talented professionals dedicated to enhancing national security.

CybersecurityDigital EngineeringHardware-in-the-Loop (HWIL)Information Assurance (IA)Modeling, Simulation, and Analysisreal-time simulationRisk Management Framework (RMF) supportsoftware assuranceSystems Engineering

digiM is a microstructure science company headquartered in Woburn, Massachusetts, founded in 2014 by Dr. Shawn Zhang. It uses 3D imaging, AI analysis, and physics-based simulation to digitize drug product microstructures and predict formulation performance, serving pharmaceutical innovators and generic developers.

3D imagingAI image analysiscomputational fluid dynamicscorrelative microscopydeep learning segmentationFIB-SEMimage-based simulationmachine learning segmentationmosaic SEMoptical microscopypolarized light microscopysynchrotron X-ray micro-CTX-ray micro-CTX-ray microscopy

FilamenTech develops multiscale mechanistic simulation workflows that help drug-development teams translate assay, tissue, animal, mutation, and structural data into human-relevant cardiac and muscle predictions. Its physics-based simulation engine MUSICO connects molecular mechanism to human-relevant cardiac function, developed through 20+ years of computational muscle modeling research and validated in translational cardiac and pharmaceutical development settings.

computational muscle modelingdata analysismechanistic simulationtranslational cardiac modeling

Forma Systems builds the intelligence layer for structural optimization in industrialized construction. Spun out of MIT's Digital Structures Research Group, the company develops optimization software for the construction industry, starting with precast concrete. Its flagship product, Cimbra, is a rapid estimation tool for precast producers that evaluates existing products against project-specific requirements.

computational designdesign generationpreliminary engineering automationstructural optimization