Neuromodulation

Bladder & Bowel Institute (BBI) is a medical practice focused on helping patients find relief from bladder and bowel control problems. Its team of gynecologists and urologists treats both men and women, and the practice describes itself as the #1 global provider of InterStim® sacral nerve stimulation therapy, with 25+ years treating bladder and bowel control problems and 10,000+ sacral nerve stimulation procedures performed. Locations include Harrison, Arkansas; McKinney, Texas; and The Woodlands, Texas.

Bulkamid implantationgynecologyimplantable tibial stimulationInterStim therapyminimally invasive hysterectomiessacral nerve stimulationurology

BIOTRONIK is a medical technology company headquartered in Berlin that develops active implants and therapies for heart disease and chronic pain. Founded on Germany's first pacemaker in 1963, it operates globally across more than 100 countries, with products developed and produced in Germany, the US, and Singapore. Its business areas include Cardiac Rhythm Management, Electrophysiology, Neuromodulation, and Micro Systems Technologies.

cardiac rhythm managementelectrophysiologyremote patient monitoringresearch and developmentsemiconductor packagingsubstrate assembly

BioWave Corporation is a Medtech company based in Westport, CT, that develops FDA-cleared, CE-certified, non-invasive neuromodulation technology for drug-free pain relief. Its patented high-frequency neurostimulation blocks pain signals at the nerve source, used in VA hospitals, professional sports, clinical settings, and at home.

clinical studieshigh frequency neurostimulationmedical device developmentnon-invasive pain reliefR&D

BrainMaster Technologies, Inc., founded in 1995, develops electroencephalographic (EEG) systems for assessment, treatment, research, and education. The company specializes in EEG-based assessment and neuromodulation, including research, development, production, education, and training. Its products are manufactured in the USA and are FDA 510K cleared as both clinical EEG and biomedical devices.

education and trainingEEG-based assessmentproductionQEEG analysisreal-time sLORETA imagingresearch and developmenttechnical support

Cellular Nanomed Inc. develops patented magnetoelectric nano-therapy technology using biocompatible magnetoelectric nanoparticles (MENPs) that, when activated by a magnetic field, generate electric fields on cancer cells to cause cell death. The technology has been tested in animal experiments, including a preclinical study at NCI Moffitt Cancer Center showing complete remission of pancreatic cancer from a single treatment. The company also works on applications including intracellular drug delivery, neuromodulation, and brain-computer interface.

brain-computer interfacemagnetoelectric nano-therapynanoparticle-based cancer treatmenttheranostics

COSMIIC offers the COSMIIC System, an open-source implantable neuromodulation platform available for adoption by researchers and startups. The system can be configured with existing stimulating and sensing modules or with new modules to support unique research requirements, and its design, documentation, and regulatory precedence enable a path through benchtop, chronic animal, and first-in-human studies.

biopotential recordingimplantable devicessensingstimulation

Elastro is a clinical stage human technology company that combines next generation neural implants with responsible machine intelligence to address neurological conditions. Its core product combines the Intelligent Neural System (INS) implant with proprietary machine intelligence, using a soft, flexible neural ribbon densely packed with electrodes that conforms to the brain's natural movement and enables bi-directional communication with thousands of neurons.

machine intelligencematerial designneural implant manufacturingsensing and stimulation

electroCore is a bioelectronic medicine company pioneering non-invasive vagus nerve stimulation (nVNS) therapy to treat conditions in neurology and metabolic disorders. Founded in 2005, the company develops proprietary vagus nerve stimulation technology and markets products including gammaCore (non-invasive vagus nerve stimulator), Truvaga, TAC-STIM, and Quell Fibromyalgia. It holds more than 200 patents and patent applications worldwide and completed an IPO on the Nasdaq Global Select Market in June 2018.

bioelectronic medicinenon-invasive vagus nerve stimulation (nVNS)

Evanesc Therapeutics, based in the Los Angeles area, is developing innovative medical devices that utilize low power RF evanescent waves for non-invasive treatment of neurological disorders and central nervous system (CNS) diseases. The company aims to increase patients' survival rates and quality of life over existing standards of care, with a management team holding over 80 years of combined experience in creating novel RF products.

non-invasive blood-brain barrier openingRF medical device development

Evren Technologies is a bioelectronic medical device company and innovator in neuromodulation technologies, transforming the treatment of Post Traumatic Stress Disorder (PTSD) by delivering noninvasive vagus nerve stimulation (VNS). It has developed the Phoenix 100, a wearable transcutaneous auricular VNS (taVNS) device resembling an earbud that delivers a light electrical tingle to activate the vagus nerve and help regulate the sympathetic and parasympathetic systems to reduce PTSD symptoms.

bioelectronic medical device developmenttranscutaneous auricular VNS (taVNS)vagus nerve stimulation (VNS)