disease modeling

AcuraStem is a patient-based biotechnology company pioneering treatments for neurodegenerative diseases including sporadic ALS and FTD. It uses its proprietary disease-modeling platform iNeuroRx® to generate individual patient models that recapitulate neurodegenerative disease processes, aiming to discover novel, effective and broadly-acting treatments. The company has a growing pipeline of antisense oligonucleotide (ASO) treatments, including lead clinical candidate AS-241.

AIantisense oligonucleotide (ASO) therapeuticsBioinformaticsbiomarker developmentdrug discoverytranslational science

Bioprinting Laboratories Inc. develops microarray three-dimensional (3D) bioprinting technology and produces injection-molded pillar/perfusion plates and accessories for static and dynamic culture of 3D cells and organoids, as well as bioprinted human organoids derived from pluripotent stem cells. Its products support 3D cell/tissue culture and predictive compound screening for the pharmaceutical, cosmetics, and chemical industries, and it offers related toxicity/efficacy assessment services.

3D cell and organoid culturecompound screeningCRISPRai gene regulation in organoidsinjection moldingmicroarray 3D bioprinting

The Center for Disease Analysis (CDA) is a public health firm with expertise in epidemiology and disease modeling. It studies complex and poorly understood diseases and publishes results to inform the community and support decision making, using a multi-disciplinary approach combining epidemiology research and advanced modeling.

developing decision toolsepidemiology researchforecasting impact of decisions

CellCure is the Stem Cell division of CiBots Inc., a Maryland Corporation with facilities in transition to doing business in San Diego, California. Founded in 2016, it focuses on drug-induced cellular reprogramming and tissue regeneration, developing small molecule partial reprogramming therapeutics for longevity, rejuvenation, healthy aging and regenerative medicine.

drug screeninghigh content analysisimagingorganoid culturesstem cell characterizationstem cell differentiationstem cell reprogrammingtissue and cell printing

CN Bio is an Organ-on-a-chip company that enables customers to generate human-specific efficacy, ADME and safety data with its PhysioMimix solutions. PhysioMimix is a suite of hardware, consumables and assay protocols that recreate complex human biology and predict human drug responses. The company also offers contract research services and support packages, and works with pharmaceutical companies and regulators on human-relevant models.

ADMEassay developmentContract Research ServicesMicrophysiological systems (MPS)Organ-on-a-chip (OOC) assaysSafety toxicology

Creative Scientist, Inc. develops customized New Approach Methodologies (NAMs), advanced human cell models, and scalable experimental platforms for drug discovery, efficacy assessment, safety evaluation, disease modeling, and mechanism-of-action studies. The company offers assay development, drug discovery and screening, drug safety and toxicology, disease modeling, advanced cell models, and molecular biology and analytical services. It also offers Volteer-96, an automated TEER measurement device, and VecStem endothelial cell culture media.

antibody-drug conjugatesantibody-RNA conjugatesassay developmentbarrier function assessmentcompound screeningcytotoxicity assessmentformulation stability testinghepatotoxicity assessmenthigh content imaginglead optimizationmechanism-of-action studiesparticle characterizationprotein expression and purificationTEER measurementvascular safety assessmentvirus-mediated gene delivery

DynamicBio Technologies develops platforms for cell culture, disease modeling, and medical devices. Its products include SimpleSoft™, a flexible 2D substrate insert that converts rigid culture plates into softer tissue-like surfaces, SimpleSoft™ 3D acellular tissue scaffolds, and VascuCore™, a biomimetic vascular construct platform under development. The company aims to create physiologically relevant human tissue models to reduce reliance on animal testing and improve drug screening.

3D tissue scaffold engineeringbiomimetic vascular construct developmentcell culture platform developmentmedical device development