computational biology

AccuraScience is a bioinformatics and computational biology service company founded in June 2013, described as the first bioinformatics service company in the U.S. to offer broad-spectrum, fully customized analysis for academic and industry researchers. It has completed more than 400 projects for over 180 institutions worldwide, and its team brings over 200 years of combined experience in bioinformatics, computational biology, and the life sciences.

16S and shotgun metagenomicsAlphaFold structural modelingATAC-seq/ChIP-seq/CUT&Tag/CUT&RUN analysisbioinformatics analysisDNA methylation analysisGWAS/EWAS/TWAS/PWASHi-C and 3D genome analysisLC-MS, GC-MS, NMR data analysismachine learning and deep learning modelingmulti-omics integrationNIH NAM grant support and modelingproteomics pipelines (DIA/TMT)RNA-seq analysissingle-cell and spatial transcriptomicsvariant callingwhole-genome/exome analysis

Aletira is developing gene therapies that use alternative splicing to control where gene expression occurs. Its selective exon, SELEXON(TM), technology harnesses alternative splicing to enable cell-type selective gene expression in therapeutic constructs. SELEXONs can be incorporated into any gene therapy platform (e.g., AAV) to ensure gene products are expressed in target cells and avoid off-target expression, improving safety, increasing potency, and accelerating development.

AIalternative splicingcell-type selective gene expressiongene therapy

Alleo Labs is a precision neuroscience company re-engineering the treatment of chronic brain disorders. It combines computational biology with brain shuttle technology to change the course of neurological diseases. Its mission is to create first-in-class, durable therapeutics targeting neuroinflammation in Parkinson's.

brain shuttle technology

Anvil Diagnostics Inc. is building next-generation molecular diagnostics for invasive infections. Its proprietary SKIP-Seq™ technology, originating from Rice University, delivers the speed of PCR with the breadth of sequencing on standard digital PCR hardware. Its MycoScan™ assay detects microbial cell-free DNA in plasma, targeting a 3-hour pan-fungal liquid biopsy, launched as a research use only (RUO) product.

algorithmic analysisassay developmentcell-free DNA detectiondigital PCR (dPCR)molecular diagnostics

Ariadne is a small business located in Rockville, MD, providing IT services to the Government focused on Bioinformatics and Data Science, Scientific Software Development, and Artificial Intelligence and Natural Language Processing (NLP). Founded in 2002 by computational biology experts, it delivers biomedical IT services and software solutions to government and commercial customers, with a mission to support health care and accelerate life science research.

Agile and DevOps practicesArtificial IntelligenceBioinformaticsbiomedical data analysisCloud and Big Data supportHigh-throughput informaticsnatural language processingproject managementscientific software developmenttext miningweb application development

Astragenyx integrates single-cell multiomics, computational biology, and machine learning, turning the complexity of human biology into a scalable engine for discovering better therapies.

machine learningsingle-cell multiomics

Biological Mimetics, Inc. (BMI) is a privately-held biomedical company located in Frederick, Maryland, USA, formed in 1996 to commercialize innovative pharmaceutical products that combat resistant and emerging diseases in human and veterinary medicine. Its mission is to join biology and engineering to identify and prevent global infections. BMI develops proprietary vaccine platforms (Immune Refocusing Technology and the 'ultra' UVC irradiation vaccine platform) and the FAST chip diagnostic device.

artificial intelligence applicationsbioinformatic analysisCRISPR diagnosticsisothermal RPA amplificationUV irradiation inactivationvaccine development

BiomEdit is an animal health biotechnology company developing Programmable Veterinary Biologics, beneficial bacteria engineered to perform specific biological functions in livestock and pets. Located inside the laboratory facilities of the Indiana Biosciences Research Institute in Indianapolis, Indiana, the company applies microbial discovery, strain engineering, computational biology, and product development to address infectious disease, chronic disease, and sustainability challenges in animal health.

AI/MLcommercializationmicrobial discoveryproduct developmentRegulatory Affairssequencingstrain engineering

Bridge Informatics provides professional bioinformatics services for biotech and pharma, helping life science companies translate genomic data into biological results. Its team of biologists, computational scientists, software engineers, and bioinformaticians offers bioinformatics analysis, data management, data mining, cloud architecture and maintenance, software and database engineering, publication services, and flexible staffing solutions. It also offers Bridge Horizon, a cloud platform for running pipelines at scale and managing data.

bioinformatics analysiscloud architectureCloud maintenancedata miningdata visualizationPipeline developmentpublication servicesSoftware & database engineeringstaffing solutions

Cambridge Data Science LLC develops AI/ML-driven computational biology and cancer genomics solutions, integrating omics data and predictive modeling to support biotech and pharmaceutical companies in drug discovery and precision medicine.

AI/MLcancer genomicsomics data integrationpredictive modeling

Cellarity is a drug discovery company that aims to solve complex diseases with medicines designed to correct the dynamic cell state. Its integrated multi-omics and AI-powered discovery platform maps networks of cell and gene interactions to predict and design oral Cell State-Correcting therapeutics that regulate gene switch mechanisms to restore proper cell function. Cellarity was launched by Flagship Pioneering in 2019.

Artificial Intelligence and Machine Learningdrug discoverymedicinal chemistrymulti-omics

Concarlo Therapeutics is a biotech company developing novel therapeutics to improve outcomes for cancer patients, using innovation in p27 biology. It is described as the first company to target CDK4/6-driven cell proliferation and CDK2-driven resistance. Its mission is to improve outcomes for patients with drug-resistant cancers by creating transformative therapies that control the p27 target.

drug discoverymedicinal chemistrypeptide therapeuticspreclinical development

ConquestBio is a Drug Discovery and Development company registered in Delaware with operations in Florida. It applies structural biology, computational biology, AI, ML and GenAI to design and discover safe and efficacious small molecule drugs at scale, focusing on biologically and clinically validated molecular targets. Its GenAI-driven platform integrates biology and pharmacology to design drugs that inhibit protein-protein interactions driving serious diseases.

AI-based drug designGenAI modelingmachine learningsmall molecule drug discoverystructural biology

DIOSynVax customises vaccine antigen design to maximise protection against existing and future viruses. Its patent-protected method combines computational biology with in vitro and in vivo validation to select Vaccine Antigen Payload (VAP) candidates. The company targets high-consequence viruses including influenza, haemorrhagic fever, and coronaviruses such as SARS-CoV-2, and partners with leading organisations to advance vaccine solutions.

Artificial IntelligenceGenomicsimmunologyin vitro validationin vivo validationpreclinical and clinical testingsynthetic biology

Duet BioSystems was formed in 2023 to commercialize science related to combination drug discovery based on its MuSyC (Multi-dimensional Synergy of Combinations) algorithm, which is cited in over 200 academic studies. The company combines expertise in computational biology and experimental design to enable mechanism-centric investigations of drug-drug interactions, working with pharma companies to more efficiently create and develop combination drug therapies.

combination drug discoverydata acquisition and analysisexperimental designmechanism-centric investigation of drug-drug interactions

Epitopea is a transatlantic cancer immunotherapeutics company based in Montreal, Canada and Cambridge, UK. It develops accessible off-the-shelf cancer RNA immunotherapies and vaccines targeting shared, aberrantly expressed tumour-specific antigens (aeTSAs), known as Cryptigen TSAs, hidden in 'junk DNA'. Its proprietary CryptoMap platform identifies these targets across difficult-to-treat cancers.

Bioinformaticsimmunogenicity assaysRNA vaccine designtarget discovery

Etiome is a biotechnology company developing and deploying Biostaged Medicines, stage-specific therapies delivered to the right patient population at the right time. By building detailed models of molecular changes over the course of disease and applying single-cell omics and artificial intelligence, Etiome uncovers hidden patterns of disease progression to identify disease-modifying targets and biomarkers. Founded in 2021, originating from Flagship Pioneering's Preemptive Health and Medicine initiative.

Artificial Intelligencebiomarker discoverydrug discoverymachine learningsingle-cell omicstarget discovery

Fauna Bio is an AI-driven drug discovery company leveraging data from 100 million years of evolved disease resistance in mammals. Using its exclusive biobank of genetic data and its in-house Convergence™ platform, it replicates how extreme animal models resist disease to create new drugs for humans. It has a multi-year $494M agreement with Eli Lilly for preclinical drug discovery in obesity, and runs space-focused research programs on hibernation and radiation protection.

AI-driven drug discoveryConvergence™ AI platformgenetic data biobankin-vivo experimentspreclinical drug discoverytarget identification

Junipero Therapeutics is an early, funded gene therapeutics company based in Durham, North Carolina, working out of BioLabs Durham. It is building a new way to control gene expression using short synthetic molecules that guide a cell's own regulators to a target RNA, raising or lowering a single gene's output without DNA cuts or viral vectors.

in vivo pharmacologymolecular and cell biologyoligonucleotide chemistry

Knowledge Synthesis accelerates and improves medical discovery by revealing the significance of large-scale experimental data across broad biological contexts. The company integrates all types of life sciences data, builds databases, search interfaces, and data analysis tools and pipelines, and works with research teams to produce findings for better medicine. It also develops iDataMed, a platform to bring Big Data to life sciences investigators.

Bioinformaticscustom visualizationsdata analysisdatabase designdata integrationproject managementsample profiling coordinationstatistical pathway analysis