cell line development

Abzena is a fully integrated biologics and bioconjugates CDMO+CRO, founded in 2001, providing discovery through commercial services for antibodies, ADCs, AOCs, RDCs, vaccines, fusion proteins, bispecifics and other complex biologics. It operates integrated facilities in San Diego CA, Bristol PA, and Cambridge UK, with corporate headquarters in Raleigh, North Carolina, and has partnered with over 500 customers globally.

analytics and bioassaysantibody discoverybioconjugationcGMP manufacturingcomplex chemistryformulation developmentHPAPI handlingimmunogenicity testingprocess developmentprotein engineeringtechnology transfer

Aragen Bioscience is a biologics research and development partner for biotechnology companies worldwide, offering discovery, development, and manufacturing services. It has three decades of experience and operates with a US-India model, with a facility in Morgan Hill, California and operations in Bengaluru, India. Its services span cell line development, bioproduction, process development, analytical development, formulation development, and GMP biologics manufacturing.

analytical development and characterisationantibody engineeringbioproductionformulation developmentGMP biologics manufacturinghistology and digital pathologyimmunology and in vitro pharmacologypreclinical efficacy testingprocess developmentrecombinant protein production

Atlas Biotech spun its mutational scanning technology out of Penn State in 2024. The company provides functional genomics services, including quantitative deep mutational scanning (qDMS) to measure dose-response and IC50 values for thousands of protein variants, custom cell line development, specificity screening (TELTALE), and functional genomics (Bypass) screens. Its work has centered on oncology, with applications in rare and inflammatory diseases.

DNA library generationdose-response analysisfunctional genomicsnext generation sequencingquantitative deep mutational scanningsaturation mutagenesisspecificity screening

Avid Bioservices is a U.S.-based biologics CDMO providing integrated mammalian cell culture process development, analytical development, formulation development, and CGMP biologics manufacturing from DNA to IND to commercial supply. It operates FDA-inspected CGMP facilities in California, including an early-phase center in Costa Mesa and commercial manufacturing in Tustin.

analytical developmentCGMP clinical manufacturingcGMP commercial manufacturingcontinuous processingdownstream processingfed-batch manufacturingformulation developmentmammalian cell cultureperfusion systemsprocess developmenttech transferupstream processing

BPS Bioscience is an ISO 9001:2015-certified company that develops research tools for drug discovery, offering a catalog of over 4500 products including proteins, cell lines, assay kits, and viral tools. The company provides screening and profiling services, custom development of proteins, cell lines, viruses, and assays, and states its products have been cited in over 4000 publications since 2010.

AAV productionassay developmentbiochemical screening and profilingBio-Layer Interferometry (BLI)cell-based screeningCRISPR/Cas9custom developmentLentivirus productionprotein production and labeling

Cells Online offers stable cell lines and primary cells for cell-based assays in drug discovery and biomedical research. Their stable cell lines include fluorescent cell lines, immortalized primary cells, knockout cell lines, immune and infectious research cell lines, CNS research cell lines, neurodegenerative disease model cell lines, GPCR cell lines, immune checkpoint cell lines, Fc Receptor cell lines, Claudin 18.2 cell lines, and apoptosis cell lines. Their primary cells include cardiac, dermal, endocrine, gastrointestinal, hepatic, neural, ocular, p

cell-based assayscloning & expressionCNS drug R&D servicesdrug screeningflow cytometry analysisfluorescent cell line developmentgene synthesisIF studyknockdown cell line developmentmammalian cell transfectionorgan-specific toxicity assaysphenotypic assaysplasmid constructionRT-PCRstable cell line development

Celltheon develops leading edge technologies and innovative solutions for the next generation of biotherapeutics. It offers platformed and custom end-to-end solutions for drug developability, cell line development, and process development to bridge the gap between early drug development and manufacturing. Located in the SF Bay Area, Celltheon has worked on 1000+ proteins for its 100+ global clients.

analytical characterizationbiochemical assay developmentbiological activity assay developmentchromatographydownstream process developmentGLP bioproduction and scale uppurificationstirred-tank bioreactor productiontech transfertox material productiontransient productionupstream process development