biocatalysis

Aralez Bio is a biotechnology company that delivers noncanonical amino acids using a pioneering enzyme platform powered by water and biocatalysis. The company produces noncanonical amino acids at commercial scale, including multi-kg batches at its Berkeley, CA plant, and emphasizes greener, sustainable chemistry for therapeutic development.

directed evolutionenzymatic synthesisprocess chemistryQA/QCscale-up manufacturing

Cambrex is a global contract development and manufacturing organization (CDMO) providing drug substance development and manufacturing across the entire drug lifecycle, as well as comprehensive analytical services and drug product services. It has more than 40 years of experience, 14-15 locations across North America and Europe, and a corporate headquarters in East Rutherford, NJ, USA.

analytical testingAPI process developmentclinical trial manufacturingcontinuous flowcontrolled substances manufacturingcrystallization process developmentcustom API manufacturingformulation developmentgeneric API manufacturinghighly potent API handlingmethod development and validationmicrobiology testingpeptide crystallizationpeptide synthesisreactor build and designsolid state chemistrystability storagetechnology transfer

Cascade Bio develops cell-free biocatalysts using its Body Armor for Enzymes™ technology, which stabilizes enzymes on easy-to-use silica beads that drop into existing processes. The company reports a 100% success rate improving enzyme stability with 17 different enzymes, and aims to transform chemical manufacturing by unlocking cascades of enzymes to make molecules using biology.

enzyme immobilizationenzyme stabilization

Dodds & Associates, established by David Dodds Ph.D., provides technical advice and management to start-up pharma, industrial biotech and renewable chemicals companies. D&A offers technical strategy, project management, due diligence, and expert witness services across organic synthesis, chiral chemistry, biocatalysis, synthetic biology, fermentation and strain development, and chem/bio process integration and scale-up.

biotransformationschem/bio process integrationchiral chemistryexpert witnessfermentation and strain developmentmolecular biologyorganic synthesisprocess development and scale-up