antibody development

AgonOx is a cancer immunotherapy company developing TIL (tumor-infiltrating lymphocyte) therapies. It isolates and expands the CD39+CD103+ subset of a patient's tumor-infiltrating lymphocytes, the fraction that is tumor-reactive. Its lead program, AGX-148, is in Phase 1 in solid tumors, with additional cell therapy programs in IND-enabling studies. The company also identifies immunotherapy targets by studying human TIL isolated from tumor types, and designs recombinant proteins, antibodies, or small molecules to block and/or activate immune-specific path

immunotherapy target identificationin-vitro human immune assaysmouse tumor modelsrecombinant protein developmentsmall molecule developmentTIL isolation and expansion

Attana AB is a Swedish life science company that provides the life science community with analytical instruments and services for bioanalysis. Its proprietary biosensor technology measures molecular interactions in real time in biologically relevant environments such as blood, plasma, living cells and tissue, helping drug developers validate, select and optimize drug candidates for Phase I and Phase II studies. The company also offers contract research (CRO) services and diagnostics through Attana Diagnostics and Attana Virus Analytics (AVA).

biosensor technologycell-based assaysdrug discovery and developmentimmunogenicity studiesinteraction analysiskinetic analysislabel-free analysistranslational researchvaccine development

AVS Bio is a USDA-licensed biologics manufacturer and supplier of avian biological materials and antibody discovery services for biopharmaceutical companies, diagnostic developers, and research institutions. Since 1961, it has provided SPF eggs, antigens, recombinant proteins, custom antibodies, and primary chicken cell products, supporting vaccines, therapeutics, diagnostics, and environmental testing worldwide.

9 CFR testingagar gel precipitin testsantibody discoverycustom assay developmentELISAhemagglutination inhibition assaysIgY antibody productionindirect fluorescent antibody testingmicroneutralization testsPCR testingserum neutralization testsserum plate agglutinationvirus production

Biocare Medical, LLC is an innovator in developing and supplying automated immunohistochemistry instrumentation and the full range of reagents for IHC lab testing. The company specializes in IHC, ISH, and FISH slide staining through its automated instrument NeoPATH Pro, and offers Multiplex IHC solutions. Customers include clinical histology laboratories, pharmaceutical companies, CROs, biotechnology companies, and academic, government, military, and non-profit laboratories. Biocare Medical is headquartered and has manufacturing facilities in California

automated slide stainingfluorescence in situ hybridizationimmunohistochemistry instrumentation manufacturingin situ hybridizationmultiplex IHC

Bioss Inc. is a Greater Boston-based life science company that develops, manufactures, and delivers research antibodies and related reagents to scientists worldwide. It has developed over 18,000 primary antibodies and more than 300,000 derived products, including fluorochrome conjugated antibodies, and offers over 2,300 antibodies recognizing phosphorylated, acetylated, or methylated proteins. Its catalog supports cancer biology, neuroscience, immunology, cell signaling, metabolism, stem cell biology, and infectious disease research.

antibody conjugationantibody manufacturingcustom recombinant rabbit monoclonal antibody development

CDI Labs provides proteomic products and services for autoantibody profiling, biomarker discovery, target identification, and antibody development. Its platforms include the HuProt™ Human Proteome Microarray (21,000+ full-length human proteins) and PhIP-Seq services such as HuScan®, MouseScan™, VirScan®, and VirScan® Exposome. The company also offers specialized CRO services including antibody development, protein production, cell therapy, and immunogenicity testing.

biomarker discoverycell therapyCRISPR-Cas9 immunogenicity testingdiagnostic developmentimmunogenicity testingmolecular glue discoverypan-proteome epitope mappingPhIP-Seqpost-translational modification specificity profilingprotein microarrayprotein productionproteome-wide autoantibody profilingtarget identification

Cell Signaling Technology (CST) develops and supplies antibodies, reagents, kits, and proteomics products for research use. The company states it has been providing antibodies for 25 years and that over 99.5% of its recombinant monoclonal antibodies are developed in-house. CST offers custom services including antibody formulations, conjugation, ELISA kits, and proteomics analysis.

custom antibody formulationcustom conjugationELISA developmentin-house manufacturingmass spectrometrypeptide synthesisProteomics analysis

CH3 BioSystems is a biotechnology company based on a patent-protected chemical technology designed to identify and commercialize drug and diagnostic candidates. Owned and run by scientists, it provides cell lines, antibodies, enzymes, expression vectors, luciferase reporters, peptides, and shRNA vectors, with a focus on protein methylation biology and epigenetic molecular tools.

cell line productionscreening technologies

Eureka Therapeutics, Inc. is a clinical-stage biopharmaceutical company located in the Bay Area developing transformative technology platforms that can access cancer-specific targets and harness the evolutionary power of T cells for the treatment of solid tumors and other malignancies. Its mission is to harness the evolutionary power of the human immune system to transform the lives of patients fighting cancer.

clinical developmentCMC/manufacturinghigh throughput screeningT-cell therapy development

GlycoScientific, LLC is a privately-held company based in Athens, Georgia, engaged in the development and commercialization of unique research reagents in the field of glycobiology, including products involving characterization of glycosylation. It develops antibodies for quantitation of specific glycan modifications, focusing on proteins involved in cancer, diabetes and neurodegenerative disorders.

glycobiology research reagentsglycoprotein standard productionmass spectrometry quantitation standards

IgGenix, Inc. is a clinical-stage antibody discovery and development company with a mission to solve allergies and other immunological diseases. Using its SEQ SIFTER™ single cell RNA-sequencing-based discovery platform, it captures rare human B cells that produce IgE antibodies from human blood and re-engineers fully human, high-affinity, allergen-specific IgG antibodies designed to block the allergic cascade. Its lead candidate IGNX001 targets peanut allergy and has completed a Phase 1 clinical trial.

antibody discoveryantibody re-engineeringclinical trialsobservational studiessingle cell RNA-sequencing

Ikaika Therapeutics is a biotech company developing first-in-class anti-fibrotic antibodies, including IKN-001, which binds LTBP4 to prevent TGF-β activation and fibrosis accumulation. Its pipeline targets fibrotic diseases including muscular dystrophy, based on genetic research identifying LTBP4 as a driver of fibrotic disease severity.

genetic researchgenome-wide mappingquantitative trait loci mapping

Immunova Therapeutics is a Los Angeles-based company focused on cancer immunotherapy, working on technologies including CAR-T cells, TCR-T cells, antibodies, and vaccines. The site describes CAR-T cells engineered to express synthetic receptors and TCR-T therapy that introduces tumor-specific T cell receptors into patient T cells.

CAR-T cell engineeringTCR-T therapyvaccine development

Kemp Proteins specializes in providing innovative solutions to protein expression problems, offering gene-to-protein bioservices for the life science and research industry. With more than 20 years of experience, its team of protein scientists has completed more than 20,000 projects, delivering timely, high-quality gene-to-protein services to help clients optimize productivity and mitigate risk in discovery, development, and manufacturing programs.

analytical characterizationBacMam expressionbaculovirus expressionbiomanufacturingcell bankingE. coli expressionhigh throughput expression and purificationhybridoma-to-recombinant conversionlyophilizationmammalian transient and stable transfectionOEM vialingprotein expressionpurificationSPR/BLI affinity characterizationstable cell line developmentyeast expression